Knowledge

An observational study of 42 older adults who took a Ca-AKG supplement for approximately seven months showed an average decrease in biological age of eight years, as measured by DNA methylation clocks. In the majority of subjects, epigenetic age decreased significantly, suggesting an anti-aging effect of Ca-AKG in humans.

Selenium plays an important role in many bodily functions. As an antioxidant, selenium helps protect cells from oxidative stress. This trace element also contributes to maintaining normal immune system function, thyroid function, and healthy hair and nails. Furthermore, the active ingredient influences telomere length, the protective caps of our chromosomes, which are linked to cellular aging. Studies suggest that adequate selenium intake slows telomere shortening, which may potentially slow the aging process.

In a pilot study in people with diabetic kidney disease, a short-term combination with the senolytic quercetin reduced markers for aging cells in adipose tissue by up to 62% and reduced signs of inflammation in the tissue; senescence markers also decreased in the skin (-20% to -31%).

In a placebo-controlled crossover study in healthy adults, NR increased NAD⁺ levels in immune cells by approximately 60% and activated similar health benefits as calorie restriction. In participants with mildly elevated blood pressure, systolic blood pressure decreased by approximately 10 mmHg, potentially corresponding to a roughly 25% lower risk of heart attack.

In a randomized, placebo-controlled, double-blind study of 118 older adults with low selenium status, daily supplementation with selenium and coenzyme Q₁₀ over 42 months resulted in significantly less shortening of telomere length compared to the placebo group. Participants with stable telomere length also had a 25% lower cardiovascular mortality rate during long-term follow-up.

In an Alzheimer's mouse model, the supplementation of NR was studied over a period of 5 months. The treatment increased NAD⁺ levels in the brain, reduced inflammatory responses, and reduced signs of cell damage and senescence in the animals' brains. Cognitive performance was also measurably improved.

In a double-blind study on middle-aged mice (18 months), Ca-AKG increased overall lifespan by ~12% and improved healthy lifespan (healthspan) by ~40–46%. Mice fed Ca-AKG showed significantly less frailty in old age, remained healthier until near the end of life, and spent a shorter time with age-related diseases.

In a laboratory study with human dermal fibroblasts (the skin's "collagen factories"), AKG boosted collagen production by approximately 12–26% compared to the untreated control, depending on the concentration. AKG supports enzymes and the provision of building blocks that facilitate collagen formation. In addition, an animal model using UV irradiation showed that a 1% AKG cream significantly reduced wrinkle formation and better preserved the skin's collagen fiber structure.